Catalog Record

Report from S&T Project 19006: Development of Dreissenid Mussel Engineered Disseminated Neoplasia

Biomilab LLC has been working for three years on a project aimed at developing, validating, and manufacturing an invasive mussel eradication agent that mimics a natural pathogenic mechanism found in marine bivalves called a disseminated neoplasia (DN). A DN is a form of cancer where the cancer cells themselves travel between organisms in a specific-species manner causing toxicity in the host. Biomilab has established invasive mussel aquaculture in their laboratory and determined methods for the prolonged survival of dissociated mussel cells in culture. They have utilized sequence data provided by Reclamation, and plasmid DNA vectors were constructed for transgene expression and tested in insect cell lines as a proxy for mussel cells. Biomilab tested more than a dozen methods of transduction on mussel cells and determined that because mitotic cells are quite rare, transduced foreign DNA cannot enter the nucleus and is not expressed. In the third year, the focus was on overcoming issues of transduction by exploring infection with recombinant viruses and by establishing methods for the controlled spawning and generation of quagga and zebra mussel embryos by in vitro fertilization.
Generation Effort S&T Project 19006: Development of Dreissenid Mussel Engineered Disseminated Neoplasia
Location Western US
Themes Biological
Tags Quagga Mussels, Invasive Mussels, Zebra Mussels, Eradication, Disseminated Neoplasia
Reclamation Project
Reclamation Program Science and Technology Program

Location Information

Location Name Western US
Location Description The 17 western states of Washington, Oregon, Idaho, Montana, North Dakota, South Dakota, Nebraska, Wyoming, California, Nevada, Utah, Colorado, Kansas, Oklahoma, Texas, New Mexico, and Arizona..
Location Tags Reclamation Domain
Location Parent
State(s) Arizona, California, Colorado, Idaho, Kansas, Montana, North Dakota, Nebraska, New Mexico, Nevada, Oklahoma, Oregon, South Dakota, Texas, Utah, Washington, Wyoming
Unified Region(s) Missouri Basin, Arkansas-Rio Grande-Texas-Gulf, Upper Colorado Basin, Lower Colorado Basin, Columbia-Pacific Northwest, California-Great Basin
Timezone MT
Elevation [ N/A ]
Vertical Datum NAVD88
Coordinates (lat, long) See Location Details
Horizontal Datum WGS84